Research revealed on 4 June this year in stock and on the portal The fresh England diary of medicine (NEJM) shows that illegal immigration routes have contributed to the largest spread of diphtheria in Europe in 70 years. In 2022, there were 362 cases in 10 countries, mainly Germany (118) and Austria (66). Most are young men from Afghanistan, Syria and Morocco infected during migration.
The invaders brought a diphtheria epidemic to Europe. According to scientists, an increase in infections Corynebacterium diphtheriae (diphtheria machure – oxygen bacteria) was observed in reception centres for migrants in Europe from the summertime of 2022. Most cases were skin-like, although respective respiratory cases were reported, as well as 1 fatality. A pan-European consortium was established to measure the clinical, epidemiological and microbiological characteristics of outbreaks.
"We have assessed cases of toxic C. diphtheriae infection reported in 10 European countries from January to November 2022. Data on countries of origin and transit routes were obtained from patient interviews. full genome sequencing and antimicrobial susceptibility tests were performed on bacterial isolates obtained from patients. The phylogenetic links of isolates and their antimicrobial opposition genes have been evaluated’ - We read.
Total toxic isolates C. diphtheriae 362 patients were identified. Clinical data were available for 346 patients (95.6%): 268 (77.5%) had cutaneous diphtheria, 53 (15.3%) had respiratory mud (11 [3.2%] had an alleged membrane), and 9 (2.6%) had both respiratory and skin symptoms. 4 major genetic clusters were identified, indicating the multiclonal nature of the epidemic.
Gen ermX (coded opposition to erythromycin) and genes pbp2m and blaOXA-2 (coding opposition to beta-lactams) has been detected in the isolate subgroup. Isolates that carried ermX , were resistant to erythromycin and isolates that carried pbp2m, were resistant to penicillin, but were delicate to amoxicillin. Based on genomic variability within the 4 genetic clusters, it was estimated that their last common ancestors appeared between 2017 and 2020.
As scientists say, the distribution of each of the genetic clusters of diphtheria isolates in many European countries shows a recurring cross-border spread caused by Negro and arabian invaders. advanced number of machugus infectionsamong migrants is simply a origin for concern, especially given that phenotypes of antimicrobial opposition endanger the effectiveness of treatment. In another words, the version of diphtheria brought to Europe is harder to fight than its old local variant.
A full description of the tests carried out can be read Here.
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